Published: Fri, December 07, 2018
Medical | By

Mother Gives Birth Using Transplanted Uterus

Mother Gives Birth Using Transplanted Uterus

A team in Brazil transplanted the womb from a dead 45-year-old woman into an infertile 32-year-old recipient, who went on to have a healthy baby girl.

The Lancet reports that the mother had Mayer-Rokitansky-Küster-Hauser syndrome, a condition that causes the uterus and vagina to not develop properly.

There have been 39 womb transplants using a live donor, including mothers donating their womb to their daughter, resulting in 11 babies. And just seven months after the operation, doctors began in vitro fertilization, through which the woman's own fertilized eggs - which had been harvested prior to the transplant surgery - were transferred to her new uterus.

Her baby girl was born via a caesarean section at 35 weeks and three days gestation, and transplanted uterus was removed during the c-section.

But there are far more women in need of transplants than there are potential live donors, so doctors wanted to find out if the procedure could work using the uterus of a woman who had died.

The first successful childbirth following uterine transplant from a living donor took place in 2014 in Sweden, and there have been 10 others since then.

In 2016, doctors at the Cleveland Clinic in OH transplanted a uterus from a deceased donor, but it failed after an infection developed.

"They should promote education and guidance so that the groups performing uterus transplantation for the first time can benefit from the experience of the pioneers".

The surgical team had to connect the donor's uterus with the veins, arteries, ligaments, and vaginal canal of the recipient.

The transplanted uterus was removed during the procedure, and no anomalies were seen.


He said: "All in all, the research to be done in this field (whether from alive or deceased donors) should maximise the live birth rate, minimise the risks for the patients involved in the procedures (donor, recipient, and unborn child), and increase the availability of organs".

She received five immunosuppression drugs, as well as antimicrobials, anti-blood clotting treatment and aspirin while in hospital.

With this recent success comes not just the promise of greater access to donor organs, but vital information on what a transplanted uterus requires to successfully carry an embryo to full term.

The uterus transplant, in this case, happened in September 2016. It is estimated that one woman out of 500 would be the victim of an abnormality of the uterus into the world. Falcone said the fact that the transplant was successful after the uterus was preserved in ice for almost eight hours demonstrated how resilient the uterus is.

In this trial, the mother was given standard doses of immune suppression medications for nearly six months, with positive results, before implantation of the embryo was completed.

In December 2017, doctors at Baylor University Medical Center in Texas announced that the first USA baby was born to a mother who received a uterus transplant from a living donor.

The mother and baby were discharged from the hospital three days after birth.

Doctors implanted the fertilized eggs seven months after the procedure. At the age of 7 months and 20 days, the baby continued to breastfeed and weighed 15 pounds, 14 ounces.

Eleven previous births have used a transplanted womb but from a living donor, usually a relative or friend.

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